Research has shown that staying up all night causes cognitive impairment similar to alcohol intoxication.
This can kick off a cycle of interrupted relaxing and poor sleep.
Even one missed night of sleep disrupts the activity of your body’s immune system.

The body produces cytokines to ward off disease and illness, but lack of sleep stops their production.
Without a night’s rest, you’re more vulnerable to infection.
And if you’ve pulled an all-nighter, you know that feeling of gnawing hunger.

That’s from an imbalance in the hormones leptin and ghrelin.
Leptin suppresses appetite while ghrelin increases the desire to eat.
During sleep deprivation, ghrelin levels rise and leptin falls, often leading to that late-nightpizzaorder.