However, her relationship with show creator Shonda Rhimes wasn’t always smooth.
The chemistry between Heigl and Justin Chambers' Alex Karev became legendary, as did their on-screen love story.
Keep reading to learn all about the feud between Rhimes and Heigl.
She told People years later that she regrets how she handled the situation.
“I could have handled it with more grace.”
When the series premiered, Heigl reflected on her experience with her first major series.
As for Izzie and Alex?
